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Results for "

urokinase inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	AMPK (2) Apoptosis (5) Factor Xa (1) IGF-1R (2) Mitophagy (2) MMP (2) PAI-1 (9) Proteasome (1) Reactive Oxygen Species (1) SARS-CoV (1) Ser/Thr Protease (12) Sodium Channel (5) TRP Channel (5)
By Research Areas:	Cancer (11) Cardiovascular Disease (6) Infection (1) Inflammation/Immunology (7) Metabolic Disease (4) Neurological Disease (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101214

UK-371804

PAI-1 Inflammation/Immunology

UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM.

UK-371804	PAI-1	Inflammation/Immunology
UK-371804 is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM.

HY-113844

Ac-Gly-Lys-OMe	Ser/Thr Protease	Others
Ac-Gly-Lys-OMe is a substrate for *urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors* on urokinase activity .

HY-122311

Orniplabin SMTP-7	Reactive Oxygen Species	Neurological Disease Inflammation/Immunology
Orniplabin (SMTP-7) is a low-molecular-weight compound that enhances plasminogen–fibrin binding, urokinase-catalyzed activation of plasminogen, and urokinase and plasminogen-mediated fibrin degradation. Orniplabin shows potential thrombolytic and anti-inflammatory effects. Orniplabin inhibits ROS .

HY-101214A

UK-371804 hydrochloride

UK-371804 hydrochloride (compound 24) is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM .
HY-N1533

28-O-β-D-Glucopyranosyl pomolic acid

28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC₅₀ at 37.82 μM .
HY-137495

GGACK

PAI-1 Ser/Thr Protease Cancer

GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like serine protease urokinase-type plasminogen activator (uPA) inhibitor .

UK-371804 hydrochloride
UK-371804 hydrochloride (compound 24) is a urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 10 nM .

28-O-β-D-Glucopyranosyl pomolic acid
28-O-β-D-Glucopyranosyl pomolic acid is a urokinase plasminogen activator inhibitor with IC₅₀ at 37.82 μM .

GGACK	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like *serine protease urokinase-type plasminogen activator (uPA)* inhibitor .

HY-16511

Upamostat 1 Publications Verification WX-671	Ser/Thr Protease PAI-1	Cancer
Upamostat (WX-671) is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor.

HY-135715

(E)-UK122 TFA

Others Others

(E)-UK122 TFA is the isomer of UK122 TFA. UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM .

(E)-UK122 TFA	Others	Others
(E)-UK122 TFA is the isomer of UK122 TFA. UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC50 of 0.2 μM .

HY-114330A

ZK824859 hydrochloride	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 hydrochloride is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-126361

ZK824190	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-114330

ZK824859	PAI-1 Ser/Thr Protease	Inflammation/Immunology
ZK824859 is an oral available and selective urokinase plasminogen activator (uPA) inhibitor with IC₅₀s of 79 nM, 1580 nM and 1330 nM for human uPA, tPA, and plasmin, respectively .

HY-126361A

ZK824190 hydrochloride	Ser/Thr Protease PAI-1	Inflammation/Immunology
ZK824190 hydrochloride is an orally available and selective urokinase plasminogen activator (uPA) inhibitor as a potential treatment for multiple sclerosis. IC₅₀s of 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively .

HY-B0285

Amiloride Maximum Cited Publications 25 Publications Verification MK-870	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride (MK-870) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-B0285A

Amiloride hydrochloride Maximum Cited Publications 25 Publications Verification MK-870 hydrochloride	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-W018723

4-Aminobenzamidine dihydrochloride 1 Publications Verification p-Aminobenzamidine dihydrochloride	Ser/Thr Protease	Cancer
4-Aminobenzamidine (p-Aminobenzamidine) dihydrochloride is a strong trypsin inhibitor, also acting as a relatively weak urokinase type plasminogen activator (uPA) inhibitor (K_i=82 μM). 4-Aminobenzamidine can inhibit growth of a human prostate tumor in SCID mice .

HY-B0149

Tranexamic acid 1 Publications Verification cyclocapron	IGF-1R AMPK MMP Mitophagy	Cardiovascular Disease Neurological Disease Cancer
Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-B0285B

Amiloride hydrochloride dihydrate Maximum Cited Publications 25 Publications Verification MK-870 hydrochloride dihydrate	Sodium Channel Apoptosis TRP Channel	Cardiovascular Disease Metabolic Disease
Amiloride hydrochloride dihydrate (MK-870 hydrochloride dihydrate) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride dihydrate is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-100415

UKI-1 WX-UK1; UKI-1C	PAI-1 Ser/Thr Protease	Cancer
UKI-1 (WX-UK1) is a potent urokinase-type plasminogen activator (uPA) inhibitor with a K_i of 0.41 μM. UKI-1 is also a low molecular weight serine protease inhibitor. UKI-1 is a potent antimetastatic agent and inhibits the invasive capacity of carcinoma cells .

HY-B0285AR

Amiloride hydrochloride (Standard) 5+ Cited Publications MK-870 hydrochloride (Standard)	Sodium Channel TRP Channel Apoptosis	Cardiovascular Disease Metabolic Disease
Amiloride (hydrochloride) (Standard) is the analytical standard of Amiloride (hydrochloride). This product is intended for research and analytical applications. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC ) and urokinase-type plasminogen activator receptor (uTPA ). Amiloride hydrochloride is a blocker of polycystin-2 (PC2; TRPP2 ) channel.

HY-B0149R

Tranexamic acid (Standard) cyclocapron (Standard)	IGF-1R AMPK MMP Mitophagy	Cardiovascular Disease Neurological Disease Cancer
Tranexamic acid (Standard) is the analytical standard of Tranexamic acid. This product is intended for research and analytical applications. Tranexamic acid (cyclocapron), a cyclic analog of lysine, is an orally active antifibrinolytic agent. Tranexamic acid attenuates the effects of severe trauma, inhibits urokinase plasminogen activator and ameliorates dry wrinkles. Tranexamic acid can used for the research of hemostasis .

HY-111056

UK122	Ser/Thr Protease	Cancer
UK122 is a potent and selective urokinase-type plasminogen activator (uPA) inhibitor with an IC₅₀ of 0.2 μM. UK122 shows no or little inhibition of tissue-type PA (tPA), plasmin, thrombin, and trypsin (all IC₅₀>100 μM). UK122, 4-oxazolidinone analogue, is an anticancer agent and inhibits cancer cell migration and invasion .

HY-B0285AS

Amiloride-15N3 hydrochloride MK-870-¹⁵N₃ hydrochloride	Apoptosis TRP Channel Sodium Channel
Amiloride- ¹⁵N₃ (hydrochloride) is the ¹⁵N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

HY-114015

APC-6860	Ser/Thr Protease	Cancer
APC-6860 is a trypsin-like serine proteases inhibitor with k_i values of 0.21 and 0.44 μM for uPA and trypsin, respectively. APC-6860 has a selectivity ratio for tPA versus uPA of 80. APC-6860 has k_i values of 0.1 and 0.082 μM for human and murine urokinases, respectively. APC-6860 can be used for the research of cancer .

HY-108447

BC-11 hydrobromide	Ser/Thr Protease SARS-CoV PAI-1	Infection Cancer
BC-11 hydrobromide is a selective TMPRSS2 inhibitor (TMPRSS2 is a key host cellular factor for viral entry and SARS-CoV-2 pathogenesis), and a selective urokinase (uPA) inhibitor (IC₅₀=8.2 μM). BC-11 hydrobromide is cytotoxic to triple-negative MDA-MB231 breast cancer cells. BC-11 hydrobromide is used in research on viral infections and cancer .

HY-B0385

Gabexate mesylate 4 Publications Verification FOY	Proteasome Factor Xa	Inflammation/Immunology
Gabexate mesylate (FOY) is is a competitive and non-antigenic synthetic inhibitor of trypsin-like serine proteinases. Gabexate mesylate inhibits human thrombin, urokinase, plasmin, and Factor Xa with K_is of 0.97, 1.3, 1.6, and 8.5 μM, respectively. Gabexate mesylate binds to human and bovine tryptase with K_is of 3.4 nM and 18 μM, respectively. Gabexate mesylate exerts an anticoagulant effect on the clotting activity of thrombin and has anti-inflammatory effect by viainhibition of NF-κB, proinflammatory cytokines, and nitric oxide. Gabexate mesylate is used for pancreatitis and disseminated intravascular coagulation .

Vitronectin	Native Proteins
Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix. Vitronectin binds glycosaminoglycans, collagen, plasminogen and the urokinase-receptor. Vitronectin also stabilizes the inhibitory conformation of plasminogen activation inhibitor-1. Vitronectin can be used for researching wound healing and in tumorprogression .

Ac-Gly-Lys-OMe	Ser/Thr Protease	Others
Ac-Gly-Lys-OMe is a substrate for *urokinase. Ac-Gly-Lys-OMe can be used to measure the effects of small molecule inhibitors* on urokinase activity .

Cenupatide	Peptides	Cancer
Cenupatide (UPARANT) is a Urokinase-type plasminogen activator receptor (uPAR) inhibitor. Cenupatide has anti-angiogenic and anti-inflammatory efficacy .

GGACK	PAI-1 Ser/Thr Protease	Cancer
GGACK (H-Glu-Gly-Arg-CMK) is an irreversible substrate-like *serine protease urokinase-type plasminogen activator (uPA)* inhibitor .

Amiloride-15N3 hydrochloride
Amiloride- ¹⁵N₃ (hydrochloride) is the ¹⁵N labeled Amiloride hydrochloride[1]. Amiloride hydrochloride (MK-870 hydrochloride) is an inhibitor of both epithelial sodium channel (ENaC[2]) and urokinase-type plasminogen activator receptor (uTPA[3]). Amiloride hydrochloride is a blocker of polycystin-2 (PC2;TRPP2[4]) channel.

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